An Untold Story of Ionic Liquid for the Isatin Derivative Synthesis

Due to its unique features and environmental benefits, green synthesis is attracting researchers worldwide. To expand the uses of ionic liquids (ILs) in green chemistry, particularly as environmentally friendly solvents and catalysts, researchers are investigating novel methods to ILs and improving their characteristics. Due to its exceptional properties, ILs have been widely utilized as a green catalyst and solvent system in the synthesis of valuable heterocyclic compounds. Aza-heterocycle isatin derivatives are regarded for their versatility in drug development and medicinal research. Organic chemists have developed isatin-based frameworks employing ILs as solvents and catalysts aligning with one of the main goals of green synthesis, maximize synthetic efficiency while reducing environmental effects. This review provides a comprehensive summarization of reports related to the ILassisted isatin derivative synthesis.