Pd‐Catalyzed Skeletal Rearrangement via C(<i>sp</i><sup>3</sup>)−C(<i>sp</i><sup>3</sup>) Activation to Access <i>α</i>,<i>β</i>‐Unsaturated <i>δ</i>/<i>γ</i>‐Lactone
Abstract The activation of non‐polar aliphatic C−C bonds represents a significant challenge that remains to be addressed in the field of Pd(II) catalysis. In this study, we present a dual ligand approach as a means of addressing this issue. The process entails lactonization of cyclobutane and cyclopropane carboxylic acid via the activation of non‐polar C( sp 3 )−C( sp 3 ) bond despite the high feasibility of both οrtho ‐C( sp 2 )−H and β or γ ‐C( sp 3 )−H activation. Density Functional Theory (DFT) calculations were performed to reveal the mechanistic insights and elucidate the role of dual ligands in facilitating this challenging transformation.
Authors
- Kartic Manna
- Puneet Gupta (ORCID: https://orcid.org/0000-0002-3004-2936)
- Nikunj Kumar (ORCID: https://orcid.org/0000-0001-8860-7824)
- Akhilesh K. Sharma (ORCID: https://orcid.org/0000-0003-2488-0754)
- Debabrata Maiti (ORCID: https://orcid.org/0000-0001-8353-1306)
- Suman Maji (ORCID: https://orcid.org/0000-0003-0704-5159)
Institutions
- Indian Institute of Technology Roorkee (IN)
- Indian Institute of Technology Bombay (IN)
Publication Details
- Journal
- Angewandte Chemie
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1002/ange.202423175
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00