Pd‐Catalyzed Skeletal Rearrangement via C( <i>sp</i> <sup>3</sup> )−C( <i>sp</i> <sup>3</sup> ) Activation to Access <i>α</i> , <i>β</i> ‐Unsaturated <i>δ</i> / <i>γ</i> ‐Lactone
The activation of non-polar aliphatic C-C bonds represents a significant challenge that remains to be addressed in the field of Pd(II) catalysis. In this study, we present a dual ligand approach as a means of addressing this issue. The process entails lactonization of cyclobutane and cyclopropane carboxylic acid via the activation of non-polar C(sp<sup>3</sup>)-C(sp<sup>3</sup>) bond despite the high feasibility of both οrtho-C(sp<sup>2</sup>)-H and β or γ -C(sp<sup>3</sup>)-H activation. Density Functional Theory (DFT) calculations were performed to reveal the mechanistic insights and elucidate the role of dual ligands in facilitating this challenging transformation.
Authors
- Kartic Manna
- Puneet Gupta (ORCID: https://orcid.org/0000-0002-3004-2936)
- Nikunj Kumar (ORCID: https://orcid.org/0000-0001-8860-7824)
- Akhilesh K. Sharma (ORCID: https://orcid.org/0000-0003-2488-0754)
- Debabrata Maiti (ORCID: https://orcid.org/0000-0001-8353-1306)
- Suman Maji (ORCID: https://orcid.org/0000-0003-0704-5159)
Institutions
- Indian Institute of Technology Roorkee (IN)
- Indian Institute of Technology Bombay (IN)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1002/anie.202423175
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.87