Comparative determination of the clinical efficacy of semi-synthetic penicillins in the treatment of pigs with Colibacteriosis

Escherichiosis occupies a leading place in infectious pathology in pig farming. Infection of animals in the neonatal and postnatal periods is too high [1]. It has been proven that in piglets in the early period, most strains of enterotoxigenic E. coli produce a thermostable enterotoxin, which, as a result of binding to receptors, leads to dehydration of the body, up to a fatal outcome. Early weaning from the mother, as well as the absence of specific antibodies in the mother's milk, prevents the formation of lactogenic immunity [3]. Despite the fact that modern measures have been developed to combat intestinal infections, this disease causes great economic losses. And the use of antibacterial drugs is an essential measure. The purpose of our trials was to comparatively determine the clinical efficacy of the semi-synthetic penicillins amoxicillin and amoxicillin in combination with succinic acid in the treatment of pigs with colibacteriosis. 80 piglets of a large white breed took part in the experiment. Therapy was received according to the following scheme: the first control group (sick animals) received the drug Amoxicillin at a dose of 0.02 g; the second experimental group (sick animals) received the drug Amoxyantar AVZ at a dose of 0.0175 g, the third control group (sick animals) did not receive the drug and served as a control; the fourth reference group (healthy animals). Animals of the first and second control groups took the drug for five days with food per kg of animal body weight. As a result of the use of the drugs Amoxicillin and Amoxyantar AVZ, it should be noted that the drug Amoxyantar at a dose of 0.0175 g per kg of animal body weight turned out to be more effective in the treatment of piglets with colibacteriosis, as evidenced by the dynamics of clinical signs, negative bacteriological results of faecal samples, as well as blood biochemistry indicators. This can be attributed to the fact that succinic acid is included in the composition of the drug. Due to it, there is an increase in the sensitivity of microorganisms to amoxicillin, there is also an increase in the permeability of the bacterial cell membrane and an increase in the contact area of the active substance with microorganisms.