Assessment of acute inhalation toxicity of Low-temperature SMOG insect® smoke generators

The purpose of this work is to calculate the parameters of acute inhalation toxicity of the low-temperature insecticide smoke generator SMOK insect®, as well as to establish its hazard class. The active ingredient in the generator is the synthetic pyrethroid cyflutrin. The research was conducted on the basis of the vivarium and the Department of Veterinary and Sanitary Examination of the St. Petersburg State University of Veterinary Medicine. The object of the study was 5 groups of laboratory rats of the Wistar line (4 experimental and 1 control). There were 6 animals in each group (3 females and 3 males). The animals were inhaled with the active substance of low-temperature SMOK insect® generators. Each of the four experimental groups received the following doses of the drug according to DV: 1 – 0.5 mg / l, 2 – 2 mg/ l, 3 – 10 mg/ l, 4 – 20 mg/ l, respectively. The control group did not receive the drug. As a result of the experiment, no dead animals were identified in group 1. In the 2nd group, 1 rat died, in the 3rd - 2, in the 4th all animals died. During the experiment, respiratory depression and asphyxia were noted in animals. The irritating effect of the drug on the mucous membranes was revealed. As a result of the conducted research, it was revealed that the drug SMOK insect® belongs to the 3rd hazard group (moderately dangerous substances) in accordance with State Standard 32646-2014.