Synthesis, Anticancer Activity, and Mitochondria-targeted Bioimaging Applications of Novel Fluorescent Calix [4]arenes-benzimidazole Derivatives

CB5-a and CB5-c were found to be the most effective against MCF-7 cells and CB5-b against HT-29 cells in the MTT test. Apoptosis analyses also proved that these compounds inhibited the proliferation of cancer cells. As a comparison compound, the synthesized CB5-R proved to be less cytotoxic than the fluorescent compounds by the MTT method, and we found the cationic compound to bind to the calix[4]arene more effectively than the molecule's binding to the diester.