Association between sex steroid hormones and α-klotho: Results from the NHANES 2013-2016 and Mendelian randomization study
In conclusion, our results demonstrate that both TT and Bio-T enhance the expression of α-Klotho in men. The positive association observed may be partly mediated by uric acid and creatinine.
Authors
- Sentai Ding
- Chenrui Wu (ORCID: https://orcid.org/0000-0002-4933-6918)
- Jishuang Cao
- Pengcheng Chen (ORCID: https://orcid.org/0000-0002-7989-0194)
- Andong Guo
Institutions
- Tongji University (CN)
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Experimental Gerontology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1016/j.exger.2025.112699
- Citations
- 2
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Natural Science Foundation of Shandong Province