ALYREF-Mediated Regulation of TBL1XR1 and KMT2E Synergistically Upregulates APOC1, Contributing to Oxaliplatin Resistance in Esophageal Cancer
This study demonstrated that ALYREF interacted with the m5C sites on TBL1XR1 and KMT2E mRNAs, enhancing their stability and leading to increased transcription of APOC1, which in turn contributed to L-OHP resistance in EC. These findings suggest that targeting APOC1 could be a promising strategy for overcoming L-OHP resistance in EC.
Authors
- Yanling Lü (ORCID: https://orcid.org/0000-0002-7458-186X)
- Qilong Liu (ORCID: https://orcid.org/0000-0002-3840-345X)
- Kai Chen (ORCID: https://orcid.org/0000-0001-6850-1723)
- Feng Bi
- Jie Hu (ORCID: https://orcid.org/0000-0002-4535-3366)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-02-04
- DOI
- https://doi.org/10.4143/crt.2024.1091
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61