Central Interaction of 2-Methoxyestradiol and Lipoxygenase in AngII-Hypertension
These data suggest that 2-methoxyestradiol protects against AngII-induced hypertension and associated pathogenesis, most likely by inhibiting LOX/12(S)-HETE actions in the PVN of female mice. Therefore, the selective LOX inhibitors or 12(S)-HETE receptor antagonists could be useful in treating hypertension and its pathogenesis in postmenopausal, hypoestrogenic women or females with ovarian failure.
Authors
- Purnima Singh (ORCID: https://orcid.org/0000-0002-0675-9128)
- Shubha Ranjan Dutta (ORCID: https://orcid.org/0000-0003-3643-1200)
- Kafait U. Malik (ORCID: https://orcid.org/0000-0001-9157-0356)
- Chi Young Song (ORCID: https://orcid.org/0000-0002-7243-6132)
- Ji Soo Shin
Institutions
- University of Tennessee Health Science Center (US)
Publication Details
- Journal
- Hypertension
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1161/hypertensionaha.124.23905
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00