Formulation and Evaluation of Mucoadhesive Herbal Patches

The present study deals with a novel approach in formulating and characterizing mucoadhesive buccal patches with the incorporation of herbal extract oil. In present area of Novel Drug Delivery System (NDDS), delivery of drugs through buccal mucosa serves an easier method for utilization of drugs leading to reduction of dose frequencies and thereby tends to sustain the drug release buccal patches were prepared with myrtus communis along with clove oil and various different polymers such as Hydroxy propyl Methyl Cellulose, Hydroxy Ethyl Cellulose, Ethyl cellulose, Chitosan in a respective solvent such as- ethanol and water including – triethanolamine, glycerine, tween 80 as excipients to enhance its property-Buccal patches were successfully formulated by solvent casting method with various concentrations of polymers and those prepared patches were characterized in terms of film thickness, film weight, colour, surface texture, folding endurance, surface, pH, and moisture content, percentage of drug content in all patches was also determined and all patches was also determined and all patches showed their significant properties upon characterization and these was uniformly in drug content for all patches. Ex-vivo studies were carried out using buccal mucosa of goat by Franz diffusion cell from the result of % drug release it was considered that the patch containing HPMC gives high drug release as compare to HEC, EC, Chitosan containing patches.