Design, Synthesis, and Molecular Docking Studies of Indolo[3,2-c]Quinolines as Topoisomerase Inhibitors
The results of this study demonstrate that compounds 5g and 8 can be considered promising candidates for further anti-cancer drug development, which might be related to inhibiting TOPO I and TOPO II activities.
Authors
- Doaa El-Khateeb
- Reem Binsuwaidan (ORCID: https://orcid.org/0000-0003-1406-282X)
- Elshaymaa I. Elmongy (ORCID: https://orcid.org/0000-0003-1160-5040)
- Husnain Ali
- Yasmine S. Moemen (ORCID: https://orcid.org/0000-0003-3173-7155)
- Ashraf A. Khalil (ORCID: https://orcid.org/0000-0001-5307-241X)
- Ibrahim El Tantawy El Sayed (ORCID: https://orcid.org/0000-0003-1227-7931)
- Mohamed Badr (ORCID: https://orcid.org/0000-0003-3596-1664)
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Menoufia University (EG)
- Helwan University (EG)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-02-04
- DOI
- https://doi.org/10.2174/0118715206360700241219065917
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00