Signs of Cortical Inflammation in Migraine Measured with Quantitative Magnetic Resonance Imaging: A Registry for Migraine (REFORM) Study
Quantitative MRI changes compatible with cortical inflammation were detected in participants with migraine, and appeared driven by the subgroup with aura. Higher occipital qT2 in migraine with aura might represent either extracellular edema or accumulation of inflammatory microglia or astrocytes. These results support the importance of cortical inflammation in migraine pathophysiology, particularly in migraine with aura. ANN NEUROL 2025;97:1168-1179.
Authors
- Reza Rahmanzadeh (ORCID: https://orcid.org/0000-0002-5091-0585)
- Haidar M. Al‐Khazali (ORCID: https://orcid.org/0000-0001-7015-3369)
- Faisal Mohammad Amin (ORCID: https://orcid.org/0000-0003-3803-3599)
- Mario Ocampo‐Pineda (ORCID: https://orcid.org/0000-0003-2239-7355)
- Håkan Ashina (ORCID: https://orcid.org/0000-0002-6268-727X)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Nouchine Hadjikhani (ORCID: https://orcid.org/0000-0003-4075-3106)
- Rune H. Christensen (ORCID: https://orcid.org/0000-0002-3384-3579)
- Messoud Ashina
Institutions
- University of Bern (CH)
- University of Copenhagen (DK)
- University of Basel (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1002/ana.27197
- Citations
- 7
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- Lundbeckfonden
- H. Lundbeck A/S