Longitudinal Assessment of Subclinical Arterial Inflammation in Patients Receiving Immune Checkpoint Inhibitors by Sequential [ <sup>18</sup> F]FDG PET Scans
This is the first controlled clinical study supporting the role of ICIs in accelerating atherosclerosis through low-grade arterial inflammation. However, although detectable by repeated [<sup>18</sup>F]FDG scans, the increase in tracer uptake associated with ICI use was modest compared with individual variability, questioning whether [<sup>18</sup>F]FDG captures the full pathophysiological process of ICI-induced, lymphocyte-driven inflammation.
Authors
- István Bojti (ORCID: https://orcid.org/0000-0003-1009-084X)
- Mark Colin Gissler (ORCID: https://orcid.org/0000-0002-5249-0174)
- Philipp T. Meyer (ORCID: https://orcid.org/0000-0001-8336-750X)
- Dennis Wolf (ORCID: https://orcid.org/0000-0003-1525-4348)
- Ingo Hilgendorf (ORCID: https://orcid.org/0000-0002-0024-1643)
- Dirk Westermann (ORCID: https://orcid.org/0000-0002-7542-1956)
- Constantin von zur Mühlen (ORCID: https://orcid.org/0000-0003-2767-8009)
- Lucas Bacmeister (ORCID: https://orcid.org/0000-0001-8240-2270)
- Alexander Maier (ORCID: https://orcid.org/0000-0003-0200-7495)
- Susanne Weber (ORCID: https://orcid.org/0000-0002-4418-3836)
- Adrian Heidenreich (ORCID: https://orcid.org/0000-0003-0756-6755)
- Annette Buellesbach (ORCID: https://orcid.org/0009-0009-3632-0042)
- Christian Goetz (ORCID: https://orcid.org/0000-0001-9524-0813)
- Niklas Hempfling
Institutions
- Zimmer Biomet (Netherlands) (NL)
- University Medical Center Freiburg (DE)
- Mahindra and Mahindra Limited (India) (IN)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
Publication Details
- Journal
- Circulation Cardiovascular Imaging
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1161/circimaging.124.016851
- Citations
- 6
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 8.16