Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia
These findings suggest that testosterone modulates inflammation in male microglia by regulating fatty acid synthesis, potentially contributing to the observed sex differences in AD pathogenesis.
Authors
- Eijiro Jimi (ORCID: https://orcid.org/0000-0003-3616-5299)
- Francisco García‐García (ORCID: https://orcid.org/0000-0001-8354-5636)
- Tomomi Sano (ORCID: https://orcid.org/0000-0001-8342-0315)
- Sergio Romera-Giner (ORCID: https://orcid.org/0000-0002-5452-8543)
- Yosuke Yamawaki (ORCID: https://orcid.org/0000-0002-7247-8295)
- Jaime Llera-Oyola (ORCID: https://orcid.org/0000-0002-0146-6641)
- Takashi Kanematsu (ORCID: https://orcid.org/0000-0001-8592-0831)
- Akiko Mizokami (ORCID: https://orcid.org/0000-0002-7490-5190)
- Haolin Zheng (ORCID: https://orcid.org/0009-0009-5517-1011)
Institutions
- Kyushu University (JP)
- Daiichi University of Pharmacy (JP)
- Centro de Investigacion Principe Felipe (ES)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13293-025-00686-8
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Ministerio de Ciencia e Innovación
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Agencia Estatal de Investigación