Novel Indexes in the Assessment of Cardiac Enlargement Using Chest Radiography: A New Look at an Old Problem

<b>Background:</b> Chest X-rays are among the most frequently used imaging tests in medical practice. We aimed to assess the prognostic value of the cardio-thoracic ratio (CTR) and transverse cardiac diameter (TCD) and compare them with novel chest X-ray parameters used in screening for cardiac enlargement. <b>Methods:</b> CTR, TCD, and five other non-standard new radiographic indexes, including basic spherical index (BSI), assessing changes in cardiac silhouette in chest radiographs in posterior-anterior projection were related to increased left ventricular end-diastolic volume (LVEDV) and left ventricular hypertrophy (LVH) assessed in cardiac magnetic resonance imaging (CMR). <b>Results:</b> TCD, CTR, and BSI were the best predictors of both LVH and increased LVEDV diagnosed in CMR. The best sensitivity, along with good specificity in LVH prediction, defined as left ventricular mass/body surface area (BSA) > 72 g/m² in men or >55 g/m² in women, was observed when TCD and BSI parameters were used jointly (69.2%, 95% confidence interval [CI]: 52.4-83.0% and 80.0%, 95% CI: 51.9-95.7%, respectively). In the prediction of cardiac enlargement defined as LVEDV/BSA > 117 mL/m² in men or >101 mL/m² in women, BSI > 137.5 had the best sensitivity and specificity (85.0%, 95% CI: 62.1-96.8% and 82.4%, 95% CI: 65.5-93.2%, respectively). <b>Conclusions:</b> TCD may be valuable in the assessment of patients suspected of having cardiac enlargement. CTR and BSI serve as complementary tools for a more precise approach. TCD appears particularly useful for the prediction of LVH, while BSI demonstrates greater utility as an indicator of increased LVEDV.