Food Intolerance and Allergy: Do They Have an Etiological Role in Idiopathic Granulomatous Mastitis?

<b>Background/Objectives:</b> Despite its long-standing recognition, the etiopathogenesis of idiopathic granulomatous mastitis (IGM) remains poorly understood. This study aims to investigate the relationship between IGM and food intolerance, allergies, and immunological factors to shed light on its etiology. <b>Materials and Methods:</b> This case-control study included 32 patients with IGM and 32 healthy women. In order to examine their potential relevance to allergy and immunology, serum interleukin (IL)-4, IL-4 receptor, histamine, and histamine-releasing factor (HRF) were measured by ELISA. Furthermore, serum IgG antibodies against specific food allergens were measured to evaluate food intolerance. <b>Results:</b> The patient group exhibited significantly higher intolerance values for lentils and curry compared to the control group (<i>p</i> = 0.023 and <i>p</i> = 0.012, respectively). Histamine (<i>p</i> < 0.001) and IL-4 (<i>p</i> = 0.003) levels were elevated in IGM patients compared to the control group, while HRF and IL-4R outcomes did not show any significant differences (<i>p</i> > 0.05). <b>Conclusions:</b> Elevated histamine and IL-4 levels may suggest the involvement of allergy and immunological factors in IGM's etiopathogenesis. The integration of anti-histamine medications for IGM patients with elevated histamine levels could provide an alternative therapeutic strategy.