In-Depth Investigation on Potential Mechanism of Forest-Grown Ginseng Alleviating Alzheimer’s Disease via UHPLC-MS-Based Metabolomics
GSF can reduce neuroinflammation and alleviate Alzheimer's disease by regulating the metabolic disorders of amino acids, sphingolipids, unsaturated fatty acids, and arachidonic acid in mice serum and brain tissue metabolites. These results suggest a link between metabolite imbalance and AD, and reveal the basis for the mechanism of ginsenosides in AD treatment.
Authors
- Huazhou Niu
- Wei Wu (ORCID: https://orcid.org/0000-0002-9633-4122)
- Hui Li (ORCID: https://orcid.org/0000-0002-3039-2813)
- Meng Zhang (ORCID: https://orcid.org/0000-0003-4497-3253)
- Kaiyue Zhang (ORCID: https://orcid.org/0009-0001-2458-0789)
- Saibire Aishan
Institutions
- Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Metabolites
- Published
- 2025-02-03
- DOI
- https://doi.org/10.3390/metabo15020093
- Citations
- 1
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- People's Government of Jilin Province