Rapid Decrease in Dextrose Concentration After Intra-Articular Knee Injection: Implications for Mechanism of Action of Dextrose Prolotherapy
This pre-post N-of-1 study shows that, after intraarticular injection of 30 mL of 12,500 mg% dextrose injection into a well knee, the concentration of dextrose diminished rapidly, suggesting that intra-articular cells, tissue, and anatomic structures are exposed to an initially high dextrose concentration for a very short time. This likely affects the mechanism of action of DPT and should inform in vitro study methods.
Authors
- Thomas Motyka
- Ian M. Thornell (ORCID: https://orcid.org/0000-0001-5535-2925)
- Yung‐Tsan Wu (ORCID: https://orcid.org/0000-0003-1175-7909)
- David Rabago (ORCID: https://orcid.org/0000-0002-1347-3603)
- Chin‐I Cheng (ORCID: https://orcid.org/0000-0002-0273-8135)
- King Hei Stanley Lam (ORCID: https://orcid.org/0000-0003-1392-829X)
- Kenneth Dean Reeves (ORCID: https://orcid.org/0000-0002-2346-2326)
- Jordan R. Atkins
- Clare R. Solso
Institutions
- University of Iowa (US)
- Tri-Service General Hospital (TW)
- Mission Health (US)
- Campbell University (US)
- Central Michigan University (US)
- Lincoln Memorial University (US)
- Chinese University of Hong Kong (HK)
- Chung Shan Medical University Hospital (TW)
- Wan Fang Hospital (TW)
- Taipei Medical University (TW)
- National Defense Medical Center (TW)
- Penn State Milton S. Hershey Medical Center (US)
- University of Hong Kong (HK)
Publication Details
- Journal
- Biomedicines
- Published
- 2025-02-04
- DOI
- https://doi.org/10.3390/biomedicines13020350
- Citations
- 2
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.44