COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression
This study highlights the pivotal role of COMMD3 in MM progression, particularly via the ATOX1-ATP7A-LOX axis. These findings provide insights into EMM mechanisms and position COMMD3 as a potential therapeutic target. Future research is needed to validate these findings in larger clinical cohorts and to unravel the precise molecular interactions between COMMD3 and copper metabolism proteins.
Authors
- Fengjuan Fan (ORCID: https://orcid.org/0000-0001-8727-5258)
- Yuhuan Zheng (ORCID: https://orcid.org/0000-0002-5855-4343)
- Yu Hu (ORCID: https://orcid.org/0000-0002-2815-4568)
- Fei Zhao (ORCID: https://orcid.org/0009-0000-1659-2141)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-8397-0680)
- Yajun Wang (ORCID: https://orcid.org/0000-0002-7557-5883)
- Jian Xu (ORCID: https://orcid.org/0000-0003-2032-251X)
- Chunyan Sun
Institutions
- Union Hospital (HK)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Biomedicines
- Published
- 2025-02-04
- DOI
- https://doi.org/10.3390/biomedicines13020351
- Citations
- 5
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology