Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic liver disease and steatohepatitis
These findings suggest that celastrol may beneficially modulate the galaninergic system under obesity and MASLD-to-MASH progression, indicating its potential as a therapeutic agent for disorders associated with metabolic dysfunction.
Authors
- Ondřej Slanař (ORCID: https://orcid.org/0000-0002-5357-7562)
- Mahak Arora (ORCID: https://orcid.org/0000-0002-7266-9833)
- Jitka Šípková
- Nikolina Kutinová Canová (ORCID: https://orcid.org/0000-0002-6701-4672)
- Zuzana Pavlíková (ORCID: https://orcid.org/0000-0001-9890-3272)
- Tomáš Vacı́k (ORCID: https://orcid.org/0000-0003-0797-7757)
- Tijana Šopin
- Ond⊘řej Šeda (ORCID: https://orcid.org/0000-0001-8498-5895)
- Tomáš Kučera (ORCID: https://orcid.org/0000-0003-2134-4657)
Institutions
- Charles University (CZ)
- Institute of Pharmacology (CZ)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.3389/fphar.2025.1476994
- Citations
- 4
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.53