Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Skin Matrix Synthesis and Pigmentation
These results highlight the potential of UC-MSC-sEVs in stimulating HDF proliferation, regulating ECM synthesis, and reducing melanin production. This demonstrates the promising application of UC-MSC-sEVs in medical aesthetics for benefits such as scar reduction, skin rejuvenation, and skin lightening.
Authors
- Nur Azurah Abdul Ghani (ORCID: https://orcid.org/0000-0002-5544-0279)
- See Nguan Ng
- Li Ting Kee (ORCID: https://orcid.org/0000-0001-6598-116X)
- Jhi Biau Foo (ORCID: https://orcid.org/0000-0002-5880-2220)
- Min Hwei Ng (ORCID: https://orcid.org/0000-0002-5791-639X)
- Chee Wun How (ORCID: https://orcid.org/0000-0002-5910-6542)
- Jia Xian Law (ORCID: https://orcid.org/0000-0001-9045-5145)
- Mohd Heikal Mohd Yunus (ORCID: https://orcid.org/0000-0002-6793-2043)
- Hong Hao Chan
Institutions
- Monash University Malaysia (MY)
- University Kebangsaan Malaysia Medical Centre (MY)
- Taylor's University (MY)
- Subang Jaya Medical Centre (MY)
- Universiti Teknologi MARA (MY)
- National University of Malaysia (MY)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/ijn.s497940
- Citations
- 5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Universiti Kebangsaan Malaysia