Monocyte–macrophage dynamics as key in disparate lung and peripheral immune responses in severe anti‐melanoma differentiation‐associated gene 5‐positive dermatomyositis‐related interstitial lung disease
Peripheral immune suppression and pulmonary immune hyperactivation characterise the distinct immune landscapes in anti-MDA5+DM with RP-ILD. Circulating monocytes transition from an immunosuppressive phenotype in the periphery to proinflammatory and profibrotic Mo-AMs in the lungs. Chemokines produced by Mo-AMs drive monocyte and other immune cell recruitment to the lungs, amplifying pulmonary inflammation.
Authors
- Xiaoman Wang (ORCID: https://orcid.org/0000-0002-7833-6108)
- Jinmin Peng (ORCID: https://orcid.org/0000-0002-4307-0717)
- Chen Yao (ORCID: https://orcid.org/0000-0002-6009-3208)
- Xingbei Dong (ORCID: https://orcid.org/0000-0002-3390-7800)
- Chanyuan Wu (ORCID: https://orcid.org/0000-0003-2710-9359)
- Jiuliang Zhao (ORCID: https://orcid.org/0000-0001-9308-2858)
- Hou‐Zao Chen (ORCID: https://orcid.org/0000-0001-6805-3182)
- Xiaoya Pei (ORCID: https://orcid.org/0000-0003-3071-8008)
- Bin Du (ORCID: https://orcid.org/0000-0002-4412-6778)
- Jun Liu (ORCID: https://orcid.org/0000-0002-9663-3317)
- Qian Wang (ORCID: https://orcid.org/0000-0002-4541-9898)
- Shuang Zhou (ORCID: https://orcid.org/0000-0001-8694-8561)
- Jia Shi (ORCID: https://orcid.org/0000-0001-5786-895X)
- Jiao Huang (ORCID: https://orcid.org/0000-0002-2619-6318)
- Xu D (ORCID: https://orcid.org/0000-0001-5008-9451)
- Xiaofeng Zeng (ORCID: https://orcid.org/0000-0001-9484-8093)
- Yangzhong Zhou
- Xueting Yuan
- Yunpeng Lv
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
- Chinese PLA General Hospital (CN)
- Westlake University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ctm2.70226
- Citations
- 11
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 14.90
Funders
- Peking Union Medical College Hospital
- National Key Research and Development Program of China
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine