Effects of aerobic training and combination of resveratrol and fisetin on brain neurogenesis signaling pathways in Alzheimer’s mice

Background and aims: Alzheimer’s disease (AD) is a brain disorder that slowly destroys memory through the destruction of neurons by activating BDNF/VEGF/FGF7 signaling. The purpose of this study was to investigate the effects of aerobic training and combination of resveratrol and fisetin on brain neurogenesis signaling pathways in Alzheimer’s mice. Methods: In this experimental study, twenty-five C57BL/6J AD mice were randomized into 5 groups, including control, AD, AD+AT, AD+RSV+Fis, and AD+AT+RSV+Fis. The mice of the AD groups became AD by injecting amyloid-beta (Aβ1)-42 into the hippocampus. The AT protocol was five days per week for eight weeks before and after AD induction. RSV and Fis with concentrations of 25 mg/kg and 20 mg/kg were used, respectively. One-way analysis of variance was utilized to compare different groups, and Tukey’s post hoc test was employed at P≤0.05. Results: AD induction caused a significant decrease in the expression of BDNF/VEGF/FGF7 genes in hippocampal (P=0.001). AT and consumption of RSV+Fis significantly increased BDNF (P=0.001), VEGF (P=0.001), and FGF (P=0.001) in hippocampal. Conclusion: It seems that AT and RSV+Fis, both alone and simultaneously, can help increase brain neurogenesis in elderly people with AD by increasing the expression of BDNF, VEGF, and FGF7 genes in the brain tissue.