Efficacy, safety, and pharmacokinetics of eribulin as monotherapy or in combination with irinotecan for patients with pediatric rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, or Ewing sarcoma
Eribulin, as monotherapy or combination therapy, exhibited a safety profile consistent with that observed previously in adult populations; however, efficacy in both studies was not considered adequate to advance investigation in these disease areas.
Authors
- Michela Casanova (ORCID: https://orcid.org/0000-0003-0368-7883)
- Andrew Bukowinski (ORCID: https://orcid.org/0000-0002-3793-9340)
- Quentin Campbell-Hewson (ORCID: https://orcid.org/0000-0003-1509-6925)
- Yan‐Zeng Jia (ORCID: https://orcid.org/0000-0003-0506-5973)
- AeRang Kim (ORCID: https://orcid.org/0000-0002-7813-5568)
- Scott M. Bradfield (ORCID: https://orcid.org/0000-0002-8344-4365)
- Francisco Bautista (ORCID: https://orcid.org/0000-0002-0421-8862)
- Udo Kontny (ORCID: https://orcid.org/0000-0002-3072-6772)
- Rachael Windsor (ORCID: https://orcid.org/0000-0002-9614-0811)
- Giuseppe Maria Milano (ORCID: https://orcid.org/0000-0002-0250-6043)
- Costanza Paoletti (ORCID: https://orcid.org/0000-0003-0162-2453)
- Christine A. Pratilas (ORCID: https://orcid.org/0000-0002-7116-0605)
- Scott C. Borinstein (ORCID: https://orcid.org/0000-0002-1721-1520)
- Alba Rubio‐San‐Simón (ORCID: https://orcid.org/0000-0001-6426-7423)
- Oneeb Majid (ORCID: https://orcid.org/0000-0003-3481-1138)
- Douglas S. Hawkins (ORCID: https://orcid.org/0000-0003-3602-1375)
- Navin Pinto (ORCID: https://orcid.org/0000-0002-8775-6710)
- Lynley V. Marshall (ORCID: https://orcid.org/0000-0002-6537-2118)
- Catherine M. Albert (ORCID: https://orcid.org/0000-0002-8101-9066)
- R. Scott
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Institute of Cancer Research (GB)
- Johns Hopkins University (US)
- Royal Victoria Infirmary (GB)
- Children's Hospital Colorado (US)
- Nemours Children's Health System (US)
- Seattle Children's Hospital (US)
- Center for Cancer and Blood Disorders (US)
- Hospital Infantil Universitario Niño Jesús (ES)
- Universitätsklinikum Aachen (DE)
- Bambino Gesù Children's Hospital (IT)
- Children's Hospital of Pittsburgh (US)
- Great North Children's Hospital (GB)
- Eisai (United Kingdom) (GB)
- Eisai (United States) (US)
- Hospital del Niño (PA)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Nemours Children's Clinic (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- University College London (GB)
- Vanderbilt University Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1016/j.esmoop.2024.104129
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eisai