Activities of Polysaccharides Derived from Commiphora Gileadensis on Colorectal Cancer Cell Lines

Background:-CRC is a common malignancy leading to cause mortality globally. Commiphora gileadensis was used to treat respiratory infections, neuralgic pain, wounds and arthritis. Methods:-Commiphora gileadensis was harvested; then polysaccharides were extracted. The antiproliferative activity was assessed on two colorectal cancer cell lines; then, an apoptosis assay was conducted to determine cell death. Polysaccharides with antiproliferative effects were digested and separated. Results:-Commiphora gileadensis separation confirmed the presence polysaccharides that showed anti-proliferative activities on SW480 and SW620 with IC50 13.15 µg/mL and 32.02 µg/mL, respectively. Cell death was activated via apopstosis on SW480, with some resistance on WS620 cell line. Discussion: The cytotoxic effects of Commiphora gileadensis polysaccharides on SW480 and SW620 were significant as it activated the cellular apoptosis pathway. Conclusion:-Commiphora gileadensis polysaccharide extracts induce cellular apoptosis on CRC cell line with potent antiproliferative activity.