Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta
The SARS-CoV-2-dependent alteration of the transcriptome of monocyte-derived macrophage (MDM)-infected cells can be linked to the chronological order of the variants' appearance in the human population. Our data suggest an evolution of VOC in modulating the host immune response, with a strong change in pace beginning with the advent of the Delta variant. MDMs exposed to Delta showed a failure in the activation of the adaptive immune response, and this correlates with the more severe symptoms developed by people affected with this SARS-CoV-2 variant.
Authors
- Claudia Carcione (ORCID: https://orcid.org/0000-0002-0305-1781)
- Vitale Miceli (ORCID: https://orcid.org/0000-0001-8922-9909)
- Nicola Cuscino (ORCID: https://orcid.org/0000-0002-2790-7257)
- Matteo Bulati (ORCID: https://orcid.org/0000-0002-3269-935X)
- Roberta Vazzana (ORCID: https://orcid.org/0000-0002-1787-552X)
- Alessia Gallo (ORCID: https://orcid.org/0000-0001-6737-9770)
- Fausto Baldanti (ORCID: https://orcid.org/0000-0002-3358-8969)
- Salvatore Castelbuono (ORCID: https://orcid.org/0009-0002-8262-8223)
- Roberto Giambruno (ORCID: https://orcid.org/0000-0002-4566-261X)
- Daniele Lilleri (ORCID: https://orcid.org/0000-0001-7747-7622)
- Pier Giulio Conaldi (ORCID: https://orcid.org/0000-0003-1994-8005)
- Josè Camilla Sammartino (ORCID: https://orcid.org/0000-0003-3707-3118)
- Irene Cassaniti (ORCID: https://orcid.org/0000-0002-3385-2088)
Institutions
- University of Pavia (IT)
- Institute for Biomedical Research and Innovation (IT)
- Ri.MED (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12967-025-06158-2
- Citations
- 3
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Ministero della Salute
- Ministero dell'Università e della Ricerca