Non-invasive imaging with ICOS-targeting monoclonal antibody for preclinical diagnosis of rheumatoid arthritis in a humanized mouse model
In this study, we first developed an optical imaging probe targeting human ICOS, Cy7-ICOS mAb. The 4-view NIRF imaging with Cy7-ICOS mAb could detect pathogenic ICOS<sup>+</sup> activated T cells with high sensitivity and specificity in vivo, which indicated the great potential of this imaging probe in RA early diagnosis.
Authors
- Yifei Xia
- Gongping Xu (ORCID: https://orcid.org/0000-0003-1359-1148)
- Zunyu Xiao (ORCID: https://orcid.org/0000-0002-9541-3419)
- Feng Yan (ORCID: https://orcid.org/0000-0001-8663-6859)
- Shuai Shao (ORCID: https://orcid.org/0000-0003-0699-1864)
- Chao Li (ORCID: https://orcid.org/0000-0002-0240-5170)
- Weiyu Chen (ORCID: https://orcid.org/0000-0003-4436-2743)
- Shao Duan (ORCID: https://orcid.org/0000-0001-5031-0929)
Institutions
- Zhejiang International Studies University (CN)
- Ningbo University (CN)
- Harbin Medical University (CN)
- The Fourth People's Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Ningbo University Affiliated Hospital (CN)
- The Fifth People’s Hospital of Suzhou (CN)
- Ningbo First Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12967-024-05899-w
- Citations
- 2
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province