Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease (Adv. Sci. 5/2025)
Biomarker for Kawasaki Disease Vasculopathy Platelet hyperreactivity is the hallmark of Kawasaki disease (KD). However, the role of platelet in KD vasculopathy remains elusive. Xiaoqiong Gu, John Hwa, Wai Ho Tang, and co‐workers find that the direct interaction of platelet and monocyte promotes TGF 1 release and monocyte activation, resulting in the burst of inflammatory cytokines. The study provides the potential use of monocyte‐platelet aggregates as a biomarker for KD vasculopathy. More details can be found in article number 2406282. [Image: see text]
Authors
- Ying Wen (ORCID: https://orcid.org/0000-0003-0329-6823)
- Wai Ho Tang (ORCID: https://orcid.org/0000-0002-2168-3491)
- Di Che (ORCID: https://orcid.org/0000-0002-0209-6961)
- Xiaoqiong Gu (ORCID: https://orcid.org/0000-0002-9558-4226)
- Zhiyong Jiang (ORCID: https://orcid.org/0000-0002-6350-7429)
- Timur O. Yarovinsky (ORCID: https://orcid.org/0000-0003-0531-2559)
- Richard L. Edelson (ORCID: https://orcid.org/0000-0002-1552-2480)
- Xuejiao Fan (ORCID: https://orcid.org/0000-0001-6859-136X)
- John Hwa (ORCID: https://orcid.org/0000-0001-7366-2628)
- Renjing Liu (ORCID: https://orcid.org/0000-0001-9099-0076)
- Lanyan Fu
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-4174-0641)
- Qian Chen (ORCID: https://orcid.org/0000-0002-1487-5479)
- Mengmeng Wang (ORCID: https://orcid.org/0000-0002-2908-6480)
- Jin Zhou (ORCID: https://orcid.org/0000-0003-0372-2554)
- Cuiping Jia
- Yinyin Xie (ORCID: https://orcid.org/0009-0008-8882-3939)
- Manli Guo (ORCID: https://orcid.org/0000-0002-0011-9162)
- Jingwen Gao (ORCID: https://orcid.org/0000-0002-9772-4608)
- Ting Wang (ORCID: https://orcid.org/0009-0003-1256-0750)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/advs.202570027
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00