Relationship between interleukin 6 and 8 with Semen characteristics in fertile patients

Infertile males were tested for the presence of interleukin-6 and interleukin-8, as well as lipid peroxidation in their sperm. A total of 75 infertile men, including 15 fertile men, were used as controls, with semen samples collected by masturbation. Malondialdehyde (MDA) production in the sperm membrane was used to assess the degree of lipid peroxidation in the membrane. Statistics were used to examine the relationship between interleukin-6 (IL-6) and interleukin-8 (IL-8) in seminal plasma and the lipid peroxidation levels in sperm membranes. There was a statistically significant difference in the concentration of IL-6 in the seminal plasma of infertile and fertile men (p 0.05) between the two groups. On the other hand, the concentration of interleukin-8 (IL-8) in the seminal plasma of infertile men was significantly higher than that of fertile men (p < 0.05), and the degree of lipid peroxidation in the seminal plasma of infertile men was significantly higher than that of fertile men (p < 0.05). In the seminal plasma, the levels of IL-6 and the process of sperm membrane lipid peroxidation were found to be positively correlated with each other (p < 0.05), while the levels of IL-8 in the seminal plasma and sperm membrane lipid peroxidation were found to be positively correlated with each other (p < 0.05). There seems to be a possible association between plasma IL-8, IL-6, sperm ranks, and sperm membrane lipid peroxidation based on these results.