Idiopathic Subglottic Stenosis and the Epithelial Interface of Host and Environment
Our novel data support an iSGS disease model in which epithelial alterations facilitate microbiome displacement, dysregulated immune activation, and localized fibrosis. Overall, these results refine our understanding of iSGS and implicate shared pathogenic mechanisms with distal airway fibrotic diseases.
Authors
- A. John Simpson (ORCID: https://orcid.org/0000-0003-4731-7294)
- Alexander T. Hillel (ORCID: https://orcid.org/0000-0001-8471-5449)
- Helen H. Boone
- Marisol Ramirez‐Solano (ORCID: https://orcid.org/0000-0001-7895-8559)
- Wonder P. Drake (ORCID: https://orcid.org/0000-0001-9406-3130)
- Quanhu Sheng (ORCID: https://orcid.org/0000-0001-8951-9295)
- Suman R. Das (ORCID: https://orcid.org/0000-0003-2496-9724)
- Kevin Motz (ORCID: https://orcid.org/0000-0002-9255-7265)
- Seesandra V. Rajagopala (ORCID: https://orcid.org/0000-0001-7176-5770)
- Britton A. Strickland
- Paula Marincola Smith (ORCID: https://orcid.org/0000-0001-9550-6626)
- Austin T.K. Hoke (ORCID: https://orcid.org/0000-0002-7262-7510)
- Celestine N. Wanjalla (ORCID: https://orcid.org/0000-0001-9159-5414)
- Meghan H. Shilts
- Hunter M. Brown (ORCID: https://orcid.org/0000-0002-2398-6031)
- Alexander H. Gelbard (ORCID: https://orcid.org/0000-0003-0078-1305)
- Jason Powell (ORCID: https://orcid.org/0000-0002-1199-8406)
- Simon Alexander Mallal (ORCID: https://orcid.org/0000-0002-7036-1309)
- Hsiu‐Wen Tsai (ORCID: https://orcid.org/0000-0002-2837-6769)
- James B. Atkinson
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Johns Hopkins Hospital (US)
- Newcastle University (GB)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Journal of the American College of Surgeons
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1097/xcs.0000000000001340
- Citations
- 6
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.11