Palladium-Catalyzed Enantioselective Stereodivergent Desymmetrization of Cyclic 1,4-Allyldiboronates
In the presence of a chiral palladium-based catalyst, 1,4-diboryl-2-alkenes undergo enantioselective cross-coupling that results in desymmetrization of the substrate structure. Depending on the reaction conditions and the choice of ligand, the reaction can occur with <i>cis</i> or <i>trans</i> selectivity, allowing the construction of an array of different substituted chiral carbocycles in an enantiomerically enriched fashion.
Authors
- Robert A. Singer (ORCID: https://orcid.org/0000-0001-9730-1261)
- Lorenzo D. Battistoni (ORCID: https://orcid.org/0000-0002-0766-0648)
- Christophe Allais (ORCID: https://orcid.org/0000-0002-3443-9391)
- James P. Morken (ORCID: https://orcid.org/0000-0002-9123-9791)
- Hao Liang (ORCID: https://orcid.org/0000-0002-0284-1888)
- Sergei Tcyrulnikov
Institutions
- Boston College (US)
- Pfizer (United States) (US)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1021/jacs.4c16020
- Citations
- 7
- Primary Topic
- Organoboron and organosilicon chemistry
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- Division of Chemistry