Quantifying the tumour vasculature environment from CD-31 immunohistochemistry images of breast cancer using deep learning based semantic segmentation
Our proposed method shows promise as a tool for studying the tumour vasculature and its relationship with surrounding cells and tissue types. Furthermore, the correlation with tumour grade highlights the clinical relevance of our approach. These findings suggest that our method could have substantial implications for improving prognostic assessments and personalizing therapeutic strategies in breast cancer treatment.
Authors
- Tristan Whitmarsh (ORCID: https://orcid.org/0000-0001-8272-9505)
- Roido Manavaki (ORCID: https://orcid.org/0000-0002-4384-6626)
- Julia Carmona-Bozo
- Emma Brown (ORCID: https://orcid.org/0000-0002-2153-2992)
- Stephen‐John Sammut (ORCID: https://orcid.org/0000-0003-4472-904X)
- Ferdia A. Gallagher (ORCID: https://orcid.org/0000-0003-4784-5230)
- Fiona J. Gilbert (ORCID: https://orcid.org/0000-0002-0124-9962)
- Sarah E. Bohndiek (ORCID: https://orcid.org/0000-0003-0371-8635)
- Elena Provenzano (ORCID: https://orcid.org/0000-0003-3345-3965)
- Ramona Woitek (ORCID: https://orcid.org/0000-0002-9146-9159)
- Florian Markowetz (ORCID: https://orcid.org/0000-0002-2784-5308)
- Carlos Caldas (ORCID: https://orcid.org/0000-0003-3547-1489)
- Wei Cope (ORCID: https://orcid.org/0000-0002-5661-3522)
Institutions
- Danube Private University (AT)
- Institute of Cancer Research (GB)
- University of Cambridge (GB)
- Breast Cancer Now (GB)
- Cancer Research UK (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Cancer Research UK Cambridge Center (GB)
- Royal Marsden Hospital (GB)
- Institute of Astronomy (RU)
- Cancer Research UK Scotland Institute (GB)
- University of San Francisco (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13058-024-01950-2
- Citations
- 5
- Primary Topic
- AI in cancer detection
- Type
- article
- Field-Weighted Citation Impact
- 12.40
Funders
- Cancer Research UK