Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation
This study reveals that FRA ameliorates HS by inducing CTSB leakage from lysosomes, causing SAT1-mediated lipid peroxidation, mitochondrial damage and MAPK signalling pathway activation, thus mediating HSF ferroptosis. Therefore, FRA could be a promising therapeutic agent for treating HS.
Authors
- Hao Lv (ORCID: https://orcid.org/0009-0004-5566-8080)
- Chuandong Wang (ORCID: https://orcid.org/0000-0003-3535-6712)
- Yaxin Xue (ORCID: https://orcid.org/0000-0003-2395-4176)
- X. Li
- Xiaofeng Shi (ORCID: https://orcid.org/0000-0003-1484-4426)
- Wei Xu (ORCID: https://orcid.org/0000-0002-8155-7155)
- Dong Han (ORCID: https://orcid.org/0000-0003-2488-2792)
- Shaotian Fu
- Danyang Zhao
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13062-025-00610-5
- Citations
- 6
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 4.78