Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women
Metabolites in amino acid, lipid, cofactor/vitamin, and xenobiotic super-pathways as well as lipid species across the phospholipid, neutral complex lipid and sphingolipid super-pathways mediated the associations of BMI in early-life and MBD in premenopausal women. This study offers insight into the biological mechanisms underlying the link between early-life adiposity and MBD, which can support future research into breast cancer prevention.
Authors
- Chongliang Luo (ORCID: https://orcid.org/0000-0003-3682-9454)
- Jingqin Rosy Luo (ORCID: https://orcid.org/0000-0003-2759-3072)
- Haixiang Zhang (ORCID: https://orcid.org/0000-0002-7311-5605)
- Myung Sik Jeon (ORCID: https://orcid.org/0000-0002-9619-9805)
- Kayla R. Getz (ORCID: https://orcid.org/0000-0001-5552-044X)
- Adetunji T. Toriola (ORCID: https://orcid.org/0000-0003-1079-2606)
- Lili Liu (ORCID: https://orcid.org/0000-0001-7733-7654)
- Liu L (ORCID: https://orcid.org/0000-0002-9330-4315)
Institutions
- Tianjin University (CN)
- Washington University in St. Louis (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13058-025-01970-6
- Citations
- 2
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- National Institutes of Health
- National Cancer Institute