Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in the brain tissue
These findings suggest that chronic administration of tangeretin at 50, 100, and 200 mg/kg, p.o. once daily, was protective in mitigating colchicine-induced cognitive impairment and associated oxidative stress. At the same time, donepezil hydrochloride did not demonstrate similar effects.
Authors
- Areej Turkistani (ORCID: https://orcid.org/0000-0002-4600-6390)
- Ahmad H. Almehmadi (ORCID: https://orcid.org/0000-0002-4162-2012)
- Mojisola Esther Karigidi (ORCID: https://orcid.org/0000-0001-8326-8413)
- Olalekan Bukunmi Ogunro (ORCID: https://orcid.org/0000-0003-0524-5958)
- Gideon Ampoma Gyebi (ORCID: https://orcid.org/0000-0002-1945-1739)
Institutions
- Durban University of Technology (ZA)
- Taif University (SA)
- University of Ibadan (NG)
- King Abdulaziz University (SA)
- KolaDaisi University
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s12906-025-04769-2
- Citations
- 8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.74
Funders
- Directorate for Biological Sciences