IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression
An increase in conjunctival IL-23 expression contributes to the induction of the DED inflammatory response through interactions with its cognate receptor on γδT cells and the promotion of their proliferation. The findings of this study suggest that the suppression of IL-17A through the blockade of IL-23R activation may be a viable target for improving the management of inflammation in DED patients.
Authors
- Peter S. Reinach (ORCID: https://orcid.org/0000-0002-3494-4523)
- Yanxiao Li (ORCID: https://orcid.org/0000-0002-0600-8711)
- Zihao Liu (ORCID: https://orcid.org/0000-0003-0394-5184)
- Wei Chen (ORCID: https://orcid.org/0000-0002-4040-6721)
- Ling Li (ORCID: https://orcid.org/0000-0002-9245-7387)
- Xinhao Zhu
- Zan Luo
Institutions
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1167/iovs.66.2.10
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Ningbo