HMGB1 Promotes Lysosome-Dependent Cell Death Induced Via Dry Eye by Disrupting Lysosomal Homeostasis
Hyperosmotic-induced HMGB1 upregulation and increased HMGB1 transfer into the cytoplasm from the nucleus underlie the loss of lysosomal membrane integrity, which increases both cathepsin release and corneal epithelial apoptosis. HMGB1 downregulation instead ameliorated these pathogenic responses.
Authors
- Decheng Xiao (ORCID: https://orcid.org/0000-0002-3047-2979)
- Jiayao Feng
- Chengjie Pan
- Xiaoyin Ma (ORCID: https://orcid.org/0000-0002-3564-1647)
- Wei Chen (ORCID: https://orcid.org/0000-0002-2339-5741)
- Jinlong Liu (ORCID: https://orcid.org/0000-0002-8251-9601)
- Zhenzhen Sun (ORCID: https://orcid.org/0000-0001-9828-7377)
- Shuang Xie (ORCID: https://orcid.org/0000-0003-4759-4160)
- Xiaojuan Hu (ORCID: https://orcid.org/0000-0001-7817-2556)
- Qinxiang Zheng
Institutions
- Jilin University (CN)
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1167/iovs.66.2.5
- Citations
- 6
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 11.27