Sonodynamic therapy with a single neoadjuvant, diffuse delivery of low-intensity ultrasound with 5-ALA in treatment naïve glioblastoma results in tumor-specific cytotoxic edema and increased apoptosis
We saw an immediate marked imaging response indicating cytotoxic edema and indications of a histopathology response from just a single treatment. Correlation to clinical outcomes and extension of overall survival remains to be seen. A Phase 1 safety study has been submitted for regulatory approval.
Authors
- Christian Thomas (ORCID: https://orcid.org/0000-0002-6642-7774)
- Juliane Schroeteler
- Louise Stögbauer
- Sabriye Şennur Bilgin (ORCID: https://orcid.org/0000-0003-1795-2596)
- Javier Villanueva‐Meyer (ORCID: https://orcid.org/0000-0002-1212-4233)
- Vijay Agarwal (ORCID: https://orcid.org/0009-0004-5040-9207)
- Michael Müther (ORCID: https://orcid.org/0000-0001-9427-5555)
- Walter Stummer (ORCID: https://orcid.org/0000-0002-3460-0640)
- Mirjam Gerwing (ORCID: https://orcid.org/0000-0002-1127-4336)
Institutions
- Montefiore Medical Center (US)
- University of California, San Francisco (US)
- University Hospital Münster (DE)
- Klinikum Osnabrück (DE)
- Neurological Surgery (US)
Publication Details
- Journal
- Journal of Neuro-Oncology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1007/s11060-025-04957-7
- Citations
- 10
- Primary Topic
- Ultrasound and Hyperthermia Applications
- Type
- article
- Field-Weighted Citation Impact
- 6.74