Treatment and Reasons for Choosing Treatment in Breast Cancer Patients Who Underwent Next-Generation Sequencing Test
The top reasons for patients not receiving the recommended genome-matched therapy were factors related to the patient, including a number of prior treatments higher than what was allowed by the eligibility criteria of the clinical trials, and poor physical condition. Most patients received four or more regimens of cytotoxic chemotherapy before NGS. NGS is only available at the late phase of treatment in Japan, which would constitute a problem for the treatment of breast cancer.
Authors
- Hitomi Sumiyoshi Okuma (ORCID: https://orcid.org/0000-0001-9639-7361)
- Ayumi Saito (ORCID: https://orcid.org/0000-0001-9302-4287)
- Tatsunori Shimoi (ORCID: https://orcid.org/0000-0002-3603-8575)
- Emi Noguchi (ORCID: https://orcid.org/0000-0003-0326-7555)
- Kan Yonemori (ORCID: https://orcid.org/0000-0002-7624-7611)
- Rui Kitadai
- Yuki Kojima (ORCID: https://orcid.org/0000-0002-1558-5510)
- Asuka Kawachi (ORCID: https://orcid.org/0000-0002-9199-8149)
- Rumi Nishimura (ORCID: https://orcid.org/0000-0003-3385-7329)
- Mai Hoshino
- Kazuki Sudo (ORCID: https://orcid.org/0000-0002-4600-9428)
- Shosuke Kita
- Aiko Maejima (ORCID: https://orcid.org/0000-0002-0106-8352)
- Munehiro Ito (ORCID: https://orcid.org/0009-0008-4751-6094)
- Takafumi Koyama (ORCID: https://orcid.org/0000-0002-2791-5572)
Institutions
- Juntendo University (JP)
- National Cancer Center Hospital East (JP)
Publication Details
- Journal
- Oncology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1159/000543732
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00