Cancer-associated fibroblasts promote pro-tumor functions of neutrophils in pancreatic cancer via IL-8: potential suppression by pirfenidone
CAFs activate neutrophils and enhance the malignant phenotype of pancreatic cancer. The interactions between cancer cells, CAFs, and neutrophils can be disrupted by PFD, highlighting a potential therapeutic approach.
Authors
- Shinji Kuroda
- Hiroshi Tazawa (ORCID: https://orcid.org/0000-0003-4658-1050)
- Atsuki Taniguchi (ORCID: https://orcid.org/0000-0003-2908-9056)
- Kanto Suemori
- Shuto Fujita
- Satoru Kikuchi (ORCID: https://orcid.org/0000-0002-7671-0696)
- Yoshihiko Kakiuchi (ORCID: https://orcid.org/0000-0003-4886-2307)
- Shunsuke Kagawa (ORCID: https://orcid.org/0000-0002-3610-8211)
- Toshiyoshi Fujiwara (ORCID: https://orcid.org/0000-0002-5377-6051)
- Fuminori Teraishi (ORCID: https://orcid.org/0000-0001-5133-2644)
- Kosei Takagi (ORCID: https://orcid.org/0000-0003-2267-2441)
- Toshiaki Ohara (ORCID: https://orcid.org/0000-0003-1557-1589)
- M. Yoshimoto
- Tomohiko Yagi
- Shohei Nogi
- Yasuo Nagai
Institutions
- Okayama University (JP)
- Okayama University Hospital (JP)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1007/s00262-025-03946-z
- Citations
- 8
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 6.38
Funders
- Okayama University
- Japan Society for the Promotion of Science