Development and optimization of an ex vivo model of corneal epithelium damage with 1-heptanol: Investigating the influence of donor clinical parameters and MSC-sEV treatment on healing capacity
1-heptanol effectively induces reproducible corneal epithelial damage, and the ex vivo organ-cultured human cornea heals the epithelium within 96 h. Diabetes and donation from heart-beating brain-deceased donors reduce healing capacity. MSC-sEV boost epithelial repair in damaged corneas.
Authors
- Mauro Krampera (ORCID: https://orcid.org/0000-0002-7280-2040)
- Umberto Rodella (ORCID: https://orcid.org/0000-0002-4910-1617)
- Ilaria Zorzi (ORCID: https://orcid.org/0000-0001-7042-6718)
- Vanessa Barbaro (ORCID: https://orcid.org/0000-0001-8760-2343)
- Stefano Ferrari (ORCID: https://orcid.org/0000-0003-3983-3328)
- Seyedmohammad Moosavizadeh (ORCID: https://orcid.org/0000-0001-7414-3248)
- Filippo Bonelli (ORCID: https://orcid.org/0000-0003-2078-6189)
- Jana D’Amato Tóthová (ORCID: https://orcid.org/0000-0003-1498-615X)
- Thomas Ritter (ORCID: https://orcid.org/0000-0001-7709-8489)
- E. Fasolo
- Diego Ponzin (ORCID: https://orcid.org/0000-0002-6038-3977)
- Alessia Di Nella
Institutions
- University of Verona (IT)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Veneto Eye Bank Foundation (IT)
Publication Details
- Journal
- The Ocular Surface
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1016/j.jtos.2025.02.002
- Citations
- 2
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- European Cooperation in Science and Technology
- Science Foundation Ireland
- Engineering and Physical Sciences Research Council
- European Regional Development Fund