Prediction of Vancomycin Area Under the Curve With Trough Concentrations Only: Performance Evaluation of Pediatric Population Pharmacokinetic Models
This study illustrates that trough concentration-based AUC24h estimation is a feasible approach in vancomycin MIPD. These findings endorse the selected models for advanced MIPD vancomycin therapy in pediatrics, although further investigation into clinical outcomes is recommended.
Authors
- Birgit C. P. Koch (ORCID: https://orcid.org/0000-0002-1202-3643)
- Tim Preijers (ORCID: https://orcid.org/0000-0001-6953-0358)
- Alan Abdulla (ORCID: https://orcid.org/0000-0002-2158-6376)
- Robert B. Flint (ORCID: https://orcid.org/0000-0002-3658-594X)
- Brenda C. M. de Winter (ORCID: https://orcid.org/0000-0002-4452-8443)
- Stef Schouwenburg (ORCID: https://orcid.org/0000-0003-1835-0749)
- Enno D. Wildschut (ORCID: https://orcid.org/0009-0005-5197-2656)
Institutions
- Erasmus MC (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Rotterdam University of Applied Sciences (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1093/infdis/jiaf059
- Citations
- 3
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- Erasmus Universitair Medisch Centrum Rotterdam