Enterococcus and Eggerthella species are enriched in the gut microbiomes of COVID-19 cases in Uganda
Our study finds that the microbiome of COVID-19 individuals is more likely to be disrupted, as indicated by decreased diversity and increased pathobiont levels. This is either a consequence of the disease or may indicate that certain microbiome states increase susceptibility to COVID-19 disease. Our findings enable comparison with cohorts previously published in the Global North, as well as support new hypotheses about the interaction between the gut microbiome and SARS-CoV-2 infection.
Authors
- Edgar Kigozi
- Moses Luutu Nsubuga (ORCID: https://orcid.org/0000-0002-5590-1741)
- Ruohong Wang
- Sarah A. Stanley (ORCID: https://orcid.org/0000-0002-4182-9048)
- Henry Ssenfuka
- Noah Baker (ORCID: https://orcid.org/0000-0002-6368-2083)
- Bernard S. Bagaya (ORCID: https://orcid.org/0000-0002-3847-2615)
- John Mukisa (ORCID: https://orcid.org/0000-0002-9208-0313)
- Rogers Kamulegeya (ORCID: https://orcid.org/0000-0001-7972-3647)
- Chang C. Liu (ORCID: https://orcid.org/0000-0002-3290-2880)
- Ashley R. Wolf (ORCID: https://orcid.org/0000-0001-8631-9837)
- Carolina Agudelo (ORCID: https://orcid.org/0000-0002-0624-3551)
- David Patrick Kateete (ORCID: https://orcid.org/0000-0001-8075-3069)
- Julius Nsubuga (ORCID: https://orcid.org/0000-0002-1191-9210)
- Alison M. Elliott (ORCID: https://orcid.org/0000-0003-2818-9549)
- Kevin Komakech
- Monica Mbabazi (ORCID: https://orcid.org/0000-0001-6621-0586)
- Emmanuel Nasinghe (ORCID: https://orcid.org/0000-0002-2797-3596)
- Giana Cirolia (ORCID: https://orcid.org/0000-0002-9407-8495)
- Moses Lutaakome Joloba (ORCID: https://orcid.org/0000-0002-0334-9983)
- Arthur Kasambula
- Fahim Yiga (ORCID: https://orcid.org/0009-0000-5067-5338)
- Patricia Mwachan
- Diana Sitenda (ORCID: https://orcid.org/0000-0001-8169-2819)
- Christopher Lubega
- Kathryn Lin (ORCID: https://orcid.org/0000-0002-7860-9989)
- Brenda Sharon Nakalanda
- Gloria Patricia Nalubega
- Jeshua T. Gustafson
- Kassim Mulumba
Institutions
- Berkeley College (US)
- International Potato Center (UG)
- Berkeley Public Health Division (US)
- Makerere University (UG)
- Uganda Virus Research Institute (UG)
- University of California, Berkeley (US)
Publication Details
- Journal
- Gut Pathogens
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1186/s13099-025-00678-4
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Science Foundation
- George Mason University
- Fast Grants
- National Institutes of Health
- McDonnell Center for Systems Neuroscience
- Medical Research Council