Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy
Our study establishes that HVEM significantly influences T cell functionality and NSCLC cell dynamics, pinpointing the HVEM-GPT2 axis as a promising target for NSCLC therapy.
Authors
- Wen Gao (ORCID: https://orcid.org/0000-0002-0749-7676)
- Chunji Chen (ORCID: https://orcid.org/0000-0003-0587-7680)
- Yuanshan Yao (ORCID: https://orcid.org/0000-0003-2440-2840)
- Bin Li (ORCID: https://orcid.org/0000-0002-8442-0154)
Institutions
- Fudan University (CN)
- Shanghai Chest Hospital (CN)
- Huadong Hospital (CN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1007/s00262-025-03949-w
- Citations
- 5
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 5.23