Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry
This study provides valuable real-world evidence that confirms the long-term efficacy of pembrolizumab outside of clinical trials. Hierarchical organization indicates ECOG-PS, age and PD-L1-TPS as the most important predictors of 5-year survival, potentially informing clinical practice.
Authors
- Andrea Napolitano (ORCID: https://orcid.org/0000-0002-7509-1555)
- Francesco Passiglia (ORCID: https://orcid.org/0000-0002-0244-5738)
- David James Pinato (ORCID: https://orcid.org/0000-0002-3529-0103)
- Martin Sebastian (ORCID: https://orcid.org/0000-0002-0404-7741)
- Lauren Young (ORCID: https://orcid.org/0000-0002-7695-7437)
- Mieke Van Hemelrijck (ORCID: https://orcid.org/0000-0002-7317-0858)
- Michele Ghidini (ORCID: https://orcid.org/0000-0001-5435-1218)
- Gabriele Minuti (ORCID: https://orcid.org/0000-0003-2363-0446)
- Rita Barros (ORCID: https://orcid.org/0000-0002-1667-7329)
- Ritujith Jayakrishnan
- Bartłomiej Tomasik (ORCID: https://orcid.org/0000-0001-5648-345X)
- Francesco Pantano (ORCID: https://orcid.org/0000-0002-2894-9686)
- Alessandro Russo (ORCID: https://orcid.org/0000-0002-3365-1972)
- Federica Pecci (ORCID: https://orcid.org/0009-0000-9289-2007)
- Edoardo Garbo (ORCID: https://orcid.org/0000-0003-2394-9895)
- Laura Mezquita (ORCID: https://orcid.org/0000-0003-0936-7338)
- Isabelle Monnet (ORCID: https://orcid.org/0000-0003-3279-9569)
- Valter Torri (ORCID: https://orcid.org/0000-0001-9541-9354)
- Diego Signorelli (ORCID: https://orcid.org/0000-0001-5507-7820)
- Joachim G.J.V. Aerts (ORCID: https://orcid.org/0000-0001-6662-2951)
- Raffaele Giusti (ORCID: https://orcid.org/0000-0003-4592-8868)
- Monica Verrico (ORCID: https://orcid.org/0000-0002-2620-3047)
- Anne‐Marie C. Dingemans (ORCID: https://orcid.org/0000-0001-6105-182X)
- So Yeon Kim (ORCID: https://orcid.org/0000-0003-4102-5880)
- Francesco Agustoni (ORCID: https://orcid.org/0000-0002-4334-1230)
- Rita Chiari (ORCID: https://orcid.org/0000-0002-7649-273X)
- Francesca Mazzoni (ORCID: https://orcid.org/0000-0002-5828-7839)
- Marianna Macerelli
- Talal El Zarif (ORCID: https://orcid.org/0000-0002-4507-2396)
- Artur Katz (ORCID: https://orcid.org/0000-0002-1811-1169)
- Biagio Ricciuti (ORCID: https://orcid.org/0000-0002-0651-2678)
- Emilio Bria (ORCID: https://orcid.org/0000-0002-2333-704X)
- Francesco Grossi (ORCID: https://orcid.org/0000-0001-8412-3136)
- Kazuki Takada (ORCID: https://orcid.org/0000-0001-6377-9291)
- Joel W. Neal (ORCID: https://orcid.org/0000-0003-3119-9334)
- Eleni Karapanagiotou
- Giulio Metro (ORCID: https://orcid.org/0000-0002-4978-9212)
- Maximilian Rost
- Paolo Bironzo (ORCID: https://orcid.org/0000-0002-2784-5076)
- Alessandra Curioni‐Fontecedro (ORCID: https://orcid.org/0000-0002-5778-5270)
- Thomas Newsom-Davis (ORCID: https://orcid.org/0000-0001-9317-3434)
- Mary J. Fidler (ORCID: https://orcid.org/0009-0004-9180-8626)
- Sukumar Kalvapudi (ORCID: https://orcid.org/0000-0003-0233-4648)
- Giannis Mountzios (ORCID: https://orcid.org/0000-0002-7780-7836)
- Jarushka Naidoo (ORCID: https://orcid.org/0000-0002-3470-8686)
- Michele De Tursi (ORCID: https://orcid.org/0000-0002-1411-1946)
- Mingjia Li (ORCID: https://orcid.org/0000-0002-3910-4179)
- Laura Moliner (ORCID: https://orcid.org/0000-0002-1532-242X)
- Leonardo Brunetti (ORCID: https://orcid.org/0000-0003-2639-4135)
- Alessandro Morabito (ORCID: https://orcid.org/0000-0002-1319-9608)
- Chiara Bennati (ORCID: https://orcid.org/0000-0002-2970-6483)
- Michele Montrone (ORCID: https://orcid.org/0000-0002-8568-7723)
- Annalisa Guida (ORCID: https://orcid.org/0000-0001-8520-7032)
- Uma Mukherjee (ORCID: https://orcid.org/0000-0001-6693-8788)
- Diego Cortinovis (ORCID: https://orcid.org/0000-0001-7611-7369)
- Marco Russano (ORCID: https://orcid.org/0000-0002-6963-3864)
- Giuseppina Rita Di Fazio
- Alex Friedlaender (ORCID: https://orcid.org/0000-0003-1956-6824)
- Federica Zoratto (ORCID: https://orcid.org/0000-0001-8387-1968)
- Elisa Roca (ORCID: https://orcid.org/0000-0001-7625-7708)
- Margarita Majem (ORCID: https://orcid.org/0000-0002-9919-7485)
- Giuseppe Tonini (ORCID: https://orcid.org/0000-0003-4442-8677)
- Andrea Camerini (ORCID: https://orcid.org/0000-0002-1436-8397)
- Alessio Cortellini (ORCID: https://orcid.org/0000-0002-1209-5735)
- Luca Cantini (ORCID: https://orcid.org/0000-0002-6294-4758)
- David O’Reilly (ORCID: https://orcid.org/0000-0001-8491-8916)
- Alberto Servetto (ORCID: https://orcid.org/0000-0003-3624-224X)
- Solange Peters (ORCID: https://orcid.org/0000-0002-0412-7143)
- Lorenza Maria Landi (ORCID: https://orcid.org/0000-0003-2604-6595)
- Alfredo Addeo (ORCID: https://orcid.org/0000-0003-0988-0828)
- Javier Baena Preysler (ORCID: https://orcid.org/0000-0002-6373-8286)
- Sai Yendamuri (ORCID: https://orcid.org/0000-0001-6654-3487)
- Alessandro Leonetti (ORCID: https://orcid.org/0000-0001-5415-6703)
- Scott Gettinger (ORCID: https://orcid.org/0000-0003-0886-6880)
- Alessandro Di Federico (ORCID: https://orcid.org/0000-0001-8877-4315)
- Federica Biello (ORCID: https://orcid.org/0000-0002-1360-989X)
- Alessandro Inno (ORCID: https://orcid.org/0000-0001-6331-6908)
- Eleni Josephides
- Bruno Vincenzi (ORCID: https://orcid.org/0000-0001-8222-9025)
- Teresa Gorría
- Taher Abu Hejleh (ORCID: https://orcid.org/0000-0002-2476-4879)
- Martin Förster (ORCID: https://orcid.org/0000-0003-3876-7269)
- Luigi Della Gravara (ORCID: https://orcid.org/0000-0002-4347-3911)
- Andrea De Giglio (ORCID: https://orcid.org/0000-0002-0731-5721)
- Avinash Aujayeb (ORCID: https://orcid.org/0000-0002-0859-5550)
- Frank Aboubakar Nana
- Madeleine Dupont (ORCID: https://orcid.org/0000-0002-1120-8363)
- Joao V. Alessi (ORCID: https://orcid.org/0000-0002-8072-5946)
- Giuseppe Lo Russo (ORCID: https://orcid.org/0000-0003-3224-2728)
- Alain Gelibter (ORCID: https://orcid.org/0000-0002-7832-5281)
- Armida D’Incecco
- Carlo Genova (ORCID: https://orcid.org/0000-0003-3690-8582)
- Mark M. Awad (ORCID: https://orcid.org/0000-0003-0928-5244)
- Jacobo Rogado (ORCID: https://orcid.org/0000-0002-9795-8762)
- Teresa Beninato (ORCID: https://orcid.org/0000-0003-0388-6655)
- Abdul Rafeh Naqash (ORCID: https://orcid.org/0000-0001-7622-720X)
- Dwight Hall Owen (ORCID: https://orcid.org/0000-0002-6598-4886)
- Nichola Awosika
- Roberto Ferrara (ORCID: https://orcid.org/0000-0001-6443-5642)
- Salvatore Grisanti (ORCID: https://orcid.org/0000-0003-3700-3590)
- Matthew J. Loza (ORCID: https://orcid.org/0000-0002-8609-118X)
- Marina Chiara Garassino
- Heather Wakelee
- Gianpaolo Spinelli
- Jack S. Bell (ORCID: https://orcid.org/0000-0002-0630-801X)
- Claudia A M Fulgenzi
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Goethe University Frankfurt (DE)
- University of Insubria (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Teramo (IT)
- University of Parma (IT)
- University of Iowa (US)
- Rush University Medical Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- Albert Einstein College of Medicine (US)
- Cliniques Universitaires Saint-Luc (BE)
- St Thomas' Hospital (GB)
- Royal Marsden NHS Foundation Trust (GB)
- Montefiore Medical Center (US)
- University College London Hospitals NHS Foundation Trust (GB)
- Johns Hopkins University (US)
- University of Fribourg (CH)
- Vita-Salute San Raffaele University (IT)
- Università Campus Bio-Medico (IT)
- King's College London (GB)
- Mario Negri Institute for Pharmacological Research (IT)
- King Hussein Cancer Center (JO)
- Policlinico Umberto I (IT)
- Northumbria Healthcare NHS Foundation Trust (GB)
- Hammersmith Hospital (GB)
- Hospital de Sant Pau (ES)
- Beaumont Hospital (IE)
- Centre Hospitalier Universitaire Vaudois (CH)
- Agostino Gemelli University Polyclinic (IT)
- Yale Cancer Center (US)
- University of Oklahoma Medical Center (US)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- University of Chieti-Pescara (IT)
- University of Chicago (US)
- Azienda Ospedaliera di Perugia (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Hospital Universitario 12 De Octubre (ES)
- Ospedale Sacro Cuore Don Calabria (IT)
- University Hospital of Geneva (CH)
- Institut Català d'Oncologia (ES)
- Azienda Unità Sanitaria Locale Della Romagna (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Hospital Clínic de Barcelona (ES)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- CTO Andrea Alesini (IT)
- Dana-Farber Cancer Institute (US)
- Azienda Ospedaliera S.Maria (IT)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Istituto Tumori Bari (IT)
- University Hospital Frankfurt (DE)
- IRCCS Ospedale San Raffaele (IT)
- Chelsea and Westminster Hospital (GB)
- Ospedale Santa Maria Goretti (IT)
- Ospedale Monaldi (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- Campus Bio Medico University Hospital (IT)
- Ospedale Policlinico San Martino (IT)
- Saiseikai Fukuoka General Hospital (JP)
- Hospital Sírio-Libanês (BR)
- Erasmus MC Cancer Institute (NL)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Henry Dunant Hospital (GR)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Ospedale Versilia (IT)
- Hôpital Intercommunal de Créteil (FR)
- Générale-Beaulieu Clinic (CH)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Hospital Universitario Infanta Leonor (ES)
- University College London (GB)
- Imperial College London (GB)
- The Ohio State University (US)
- University of Turin (IT)
- University of Milano-Bicocca (IT)
- University of Naples Federico II (IT)
- Gdańsk Medical University (PL)
- University of Brescia (IT)
- Sapienza University of Rome (IT)
- University of Bologna (IT)
- Stanford University (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010674
- Citations
- 15
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 15.68
Funders
- International Association for the Study of Lung Cancer
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro
- Università Cattolica del Sacro Cuore