Dysbiotic oral microbiota-derived kynurenine, induced by chronic restraint stress, promotes head and neck squamous cell carcinoma by enhancing CD8<sup>+</sup> T cell exhaustion
CRS-induced oral microbiota dysbiosis plays a protumourigenic role in HNSCC and can influence host metabolism. Mechanistically, under stress conditions, Kyn promotes CD8<sup>+</sup> T cell exhaustion and HNSCC tumourigenesis through stabilising AhR by its deubiquitination.
Authors
- Bing Yang (ORCID: https://orcid.org/0000-0002-0408-4518)
- Ning Kang (ORCID: https://orcid.org/0000-0002-5377-0039)
- Fangzhi Lou
- Shihong Luo
- Xin Jin (ORCID: https://orcid.org/0000-0002-3159-2761)
- Yunmei Dong (ORCID: https://orcid.org/0000-0002-7252-3359)
- Juncai Pu (ORCID: https://orcid.org/0000-0001-9841-0291)
- Richard D. Cannon (ORCID: https://orcid.org/0000-0002-5398-2066)
- Yan Li (ORCID: https://orcid.org/0000-0003-1963-839X)
- Haiyang Wang (ORCID: https://orcid.org/0000-0001-6148-4924)
- Peng Xie (ORCID: https://orcid.org/0000-0002-0081-6048)
- Ping Ting Ji (ORCID: https://orcid.org/0000-0002-2608-1035)
- Jingyi Xu (ORCID: https://orcid.org/0009-0002-8743-7979)
- Yiyun Liu (ORCID: https://orcid.org/0000-0002-1269-2441)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- University of Otago (NZ)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1136/gutjnl-2024-333479
- Citations
- 17
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.82
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Chongqing