Genomic landscape of clinically acquired resistance alterations in patients treated with KRASG12C inhibitors
Acquired RAS/MAPK alterations are recurrent drivers of resistance to KRAS<sup>G12C</sup>i detected in CRC and, less frequently, in NSCLC. Preclinical data suggest that novel (K)RAS inhibitors may overcome many of these resistance alterations.
Authors
- Jakob M. Riedl (ORCID: https://orcid.org/0000-0002-5144-4715)
- Scott Kopetz (ORCID: https://orcid.org/0000-0001-9647-3416)
- Christine Megerdichian Parseghian (ORCID: https://orcid.org/0000-0002-2047-097X)
- Haley Ellis (ORCID: https://orcid.org/0000-0002-4915-9640)
- Ferran Fece de la Cruz (ORCID: https://orcid.org/0000-0003-2694-4838)
- Bryanna L. Norden (ORCID: https://orcid.org/0000-0003-2084-473X)
- Ryan Bruce Corcoran (ORCID: https://orcid.org/0000-0001-8173-5778)
- Leontios Pappas (ORCID: https://orcid.org/0000-0002-0589-8265)
- Haley Barnes (ORCID: https://orcid.org/0000-0003-2190-8969)
- Bennett Adam Caughey (ORCID: https://orcid.org/0000-0002-3970-1651)
- A.R. Parikh
- Preeti Patel (ORCID: https://orcid.org/0000-0003-1606-2241)
- Rebecca S. Heist (ORCID: https://orcid.org/0000-0002-7397-2009)
- Sara Ehnstrom
- Samuel Jacob Klempner (ORCID: https://orcid.org/0000-0002-4062-0808)
- Justin F. Gainor (ORCID: https://orcid.org/0000-0001-8697-4081)
- W. Marston Linehan (ORCID: https://orcid.org/0000-0001-7373-3916)
- Aaron N. Hata (ORCID: https://orcid.org/0000-0002-6127-318X)
- Alvin A. Morales-Giron (ORCID: https://orcid.org/0009-0006-0534-2634)
- Jonathan Kim (ORCID: https://orcid.org/0000-0003-2594-3251)
- Hiroyuki Matsubara (ORCID: https://orcid.org/0000-0002-9279-5458)
- H. Nakamura
- Erich James Kushner
- A Vakaris
Institutions
- Harvard University (US)
- Medical University of Graz (AT)
- University of Ulsan (KR)
- Massachusetts General Hospital (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Annals of Oncology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1016/j.annonc.2025.01.020
- Citations
- 28
- Primary Topic
- Protein Kinase Regulation and GTPase Signaling
- Type
- article
- Field-Weighted Citation Impact
- 22.57
Funders
- Austrian Science Fund
- National Institutes of Health
- Stand Up To Cancer
- National Cancer Institute