Utility of p53 and p16 immunohistochemistry in the diagnosis of human papillomavirus‐associated oral epithelial dysplasia: a retrospective study of 105 patients
The combination of p16 positivity and a basal-sparing pattern of p53 is predictive of HR HPV in OED, eliminating the need for further HPV-specific testing. Although HPV OED may co-occur with invasive squamous cell carcinoma on biopsy, the transformation to malignancy is low.
Authors
- Yen Chen Kevin Ko (ORCID: https://orcid.org/0000-0001-6081-5971)
- Zia A. Khan (ORCID: https://orcid.org/0000-0003-1682-5720)
- Erin Chapman
- Lawrence Lee (ORCID: https://orcid.org/0000-0001-6307-0194)
- Christina McCord (ORCID: https://orcid.org/0000-0002-4541-2282)
- Linda Jackson‐Boeters (ORCID: https://orcid.org/0000-0001-9630-2879)
- Kelly Yi Ping Liu (ORCID: https://orcid.org/0000-0003-4067-6913)
- Mark Darling (ORCID: https://orcid.org/0000-0002-5404-2201)
- Damir Rošić
- Tony Ng (ORCID: https://orcid.org/0000-0003-3064-8222)
Institutions
- Western University (CA)
- University of British Columbia (CA)
- University of Alberta (CA)
- London Health Sciences Centre (CA)
- Spinal Cord Injury BC (CA)
- Vancouver General Hospital (CA)
- Interface Biologics (Canada) (CA)
- Occupational Cancer Research Centre (CA)
Publication Details
- Journal
- Histopathology
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1111/his.15413
- Citations
- 3
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.40