Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU
Our results provide novel evidence of a feedback loop between cancer cells and TAMs in glucose-deficient regions. HNSCC-derived CXCL8 favors endogenous antioxidative processes and confers therapeutic resistance to nutrient-starvation therapies in HNSCC.
Authors
- Xin Hu (ORCID: https://orcid.org/0009-0002-6933-4917)
- Yikang Ji (ORCID: https://orcid.org/0009-0002-0950-9383)
- Xinhua Pan (ORCID: https://orcid.org/0000-0002-0308-3783)
- Xu Wang (ORCID: https://orcid.org/0000-0001-9064-2434)
- Zhihui Li (ORCID: https://orcid.org/0000-0002-0336-1544)
- Zhen Zhang (ORCID: https://orcid.org/0000-0002-7873-5272)
- Mi Zhang (ORCID: https://orcid.org/0000-0003-1601-8363)
Institutions
- Shanghai Jiao Tong University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Shanghai Stomatological Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Cancer Institute (CN)
- National Clinical Research (US)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1186/s13046-025-03298-7
- Citations
- 8
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- National Natural Science Foundation of China