Associations between hypovitaminosis D, adiposity indices and insulin resistance in adolescents: mediation analyses from NHANES 2011–2018
The study confirmed significant correlations between adiposity indices, hypovitaminosis D, and IR in adolescents, with gender-specific differences in the hypovitaminosis D -adiposity link. Cholesterol was found to have a more substantial influence on IR than BMI and FMI. Furthermore, FMI was identified as a more potent mediator of the hypovitaminosis D-IR relationship compared to BMI, highlighting its importance in the pathophysiology of insulin resistance in adolescents.
Authors
- Yingting Luo (ORCID: https://orcid.org/0009-0003-3477-4899)
- Yaping Deng (ORCID: https://orcid.org/0000-0001-5091-727X)
- Wei Cao (ORCID: https://orcid.org/0000-0003-1481-6310)
- Yong Zhao (ORCID: https://orcid.org/0000-0001-9290-109X)
- Jie Cao (ORCID: https://orcid.org/0000-0001-6058-4608)
- Lijuan Xu (ORCID: https://orcid.org/0000-0002-9533-362X)
- Yilei Shen (ORCID: https://orcid.org/0009-0000-4928-5754)
- Lin Kong
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Sichuan University (CN)
- National Health and Family Planning Commission (CN)
- Taiwan Centers for Disease Control (TW)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Nutrition and Diabetes
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1038/s41387-025-00358-x
- Citations
- 3
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Health Commission of the People's Republic of China
- Centers for Disease Control and Prevention